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In terms of standard tuning, there's a trade off between tone and how bendable a string is. Thicker strings give a fuller tone but break easier and aren't so easy to bend. Thinner strings are easier to bend and a little bit better for playing quickly.
In terms of alt-tunings, you want a string that's not going to break - so if you're tuning above the high e, a thinner string will hold out longer than the standard ones. There's a graph of 'best gauge to string' somewhere, I might look for it tomorrow.
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Originally Posted by Savage Clone
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