to summarize succinctly
1) there is a difference between toxic and psychoactive by every definition. toxicity harms the body and the brain, psychoactivity is when a chemical is similar to natural neurochemicals and so activates parts of the brain. very very different ideas. can some psychoactive substances also be toxic? YES OF COURSE, but that is where LD50 and a therapeutic ratio comes into play. Would you say cannabis is toxic? Serious question.
here is the definition of toxic.
describes a chemical or material that has the ability to seriously injure biological tissue Psilocybin does not have an ability to injure biological tissue unless consumed in EXTREME quantities..
2) psilocybin acts differently on the brain than LSD or other hallucinogens so we can't generalize. Yes it acts on seratonin receptors but not in the same way as LSD and it also doesn't bind with dopamine receptors like LSD. Further psilocybin acts on receptors in different regions of the brain than LSD does... TOTALLY DIFFERENT PHARMACODYNAMICS
3) everyone is different but my only beef here is this idea you expressed of mushrooms being "poisonous" and that the effects are somehow a toxic reaction? So is that what smoking weed is too? This is a classic high school myth. Psilocybin is PSYCHOACTIVE, the high is just that a high. It is not some kind of toxic reaction. The body is not harmed or reacting to something harmful. its simply what psilocybin does. Indeed some smart people have suggested its been an integral part of human evolution, that we have evolved in part by consuming psychoactive substances such as psilocybin precisely because we have observed it causes the brain to literally expand in function and neuroplasticity..
PLEASE READ THE ARTICLES I POSTED