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Originally Posted by Dead-Air
Even the Beatles had little impact on global politics or the way society is structured.
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I sort of agree with that, but with such a thin pool to choose from I think I would give it to them. They're as global as music gets, and they did extend somewhat beyond music.
I think the topic is just too specific to get many contenders. Even artists like B.B. King--he broke boundaries, but that was still mostly an American thing.
I don't think there are many musicians who have "profoundly" affected the world, but I would still nominate Bono. Sorry.