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Originally Posted by Severian
LSD, MDMA are definitely interfere more severely with neurochemical activity than psilocybin. MDMA is probably the worst, from my experience anyway.
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its because both LSD is an agonist for a wider variety of serotonin receptors in more parts of the brain and also because it also is an agonist for D2 dopamine receptors which amplify the serotonin effect. i always agreed with you that this is the neurochemical come down from LSD, i just disagreed with applying same to psilocybin which acts very differently on the brain