Lebron didn't have a chance at that. He was clearly exhausted from taking a career high in FGA while also getting a handful of hours of sleep from traveling...
Wilt did it because the NBA sucked in his era, and he was feasting on its suckiness. Ever wonder why Wilt looked like he didn't give a flying fuck in that famous picture of his 100 point game? Ever wonder why Wilt clearly just didn't ever even give a flying fuck about basketball most of the time? Simple. 1960s NBA might have well been the 1860s, it sucked. Also, this whole 1980s/90s "tough guy" basketball also sucked in comparison. All guys could do was shove each other around a bit more, now? Even if guys wasted their time trying to be "tough guys" and started shoving and playing "more physical" they'd just get burned by a quick pass and wide open elbow jump shot or catch and shoot 3
Literally, I believe that if you put some 1990s NBA players on the court today they'd look lost on defense, and get harassed into an inefficiency whole like **coughs** #StayMelo