When Homer first eats the Ribwich, the pupil-expanding, blood-cell-rushing effects parody "Requiem For A Dream".
Krusty (from his limo): People, we've been through something strange and magical together.
Listen, about the Ribwich. We won't be making them anymore. The animal we made them from is now extinct.
Homer
: The pig?
Otto: The cow?
Krusty
: You're way off. Think smaller...think more legs.
Crowd
: Ewww!