Listening to a Phil Spector boxed set, it was the Ronettes that blew my mind with the biggest mushroom cloud. Not sure if that counts, although when the Wrecking Crew was the band, there was female bassist.
Is it obvious to mention The Raincoats? Yet, I rarely hear mention of their second, Odyshape or their third, Moving. Come to think of it, some dudes play on the later two. Still. Odyshape kind of reminds me of PIL's Flowers, and I think it's a bit better.