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Given our massive presence here on the planet, and our ability to combat things, its unlikely that one phenomenon could wipe us out altogether.
But there seem to be a variety of factors such as terrorism, problems with food, natural disasters, diseases such as bird flu etc that, potentially, are poised to hit us all at once, although it may never happen. Combine those with the possibility of nuclear war sometime soon(ish) and we could be in serious trouble.
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